Which Drugs Interact Negatively with CBD in Dogs?

Here at Lolahemp, we want to make sure our customers are using our full-spectrum hemp oil for dogs responsibly. One issue that dog owners need to be aware of is the fact that cannabidiol (CBD) has the potential to interact with other veterinary medications.

This article will explore how these interactions might occur, emphasizing the importance of working with your vet before giving hemp products to your dog if they are taking other medications.

Which Drugs Can Interact with CBD?
Liver Enzymes in the Cytochrome P450 Family
Can Other Things Interfere with the CYP450 Pathway?
Conclusion

<p><span style="font-weight: 400;">Here at Lolahemp, we want to make sure our customers are using our <a href="https://lolahemp.com/blogs/pet-cbd/cbd-oil-for-your-dog-everything-you-need-to-know" title="This article discusses everything pet owners need to know in order to use hemp oil for dogs effectively.">full-spectrum hemp oil for dogs</a> responsibly. One issue that dog owners need to be aware of is the fact that cannabidiol (CBD) has the potential to interact with other veterinary medications. </span></p>
<p><span style="font-weight: 400;">This article will explore how these interactions might occur, emphasizing the importance of working with your vet before giving hemp products to your dog if they are taking other medications. </span><b></b></p>
<h2><b>Which Drugs Can Interact with CBD?</b></h2>
<p><span style="font-weight: 400;">About 60% of pharmaceutical drugs used in human medicine use the CYP450 metabolic pathway. In </span><span style="font-weight: 400;">veterinary medicine</span><span style="font-weight: 400;">, many of the </span><span style="font-weight: 400;">drugs</span><span style="font-weight: 400;"> prescribed to our pets also use this metabolic pathway. Please consult with your vet about the use of CBD oil if your dog is taking any other medications. </span></p>
<p><span style="font-weight: 400;">Represented in the table below are some of the more commonly prescribed veterinary drugs that can interact with CBD. Note: this is not an exhaustive list, so again, it is critical to consult with your vet first. </span></p>
<div style="text-align: center;"><img src="https://cdn.shopify.com/s/files/1/0030/7435/9366/files/cbd_and_drug_interactions_2-min_grande_7b48b5ed-214a-4ac5-be31-00e9e8005118_large.jpg?v=1590559099" alt="Infographic of veterinary drugs that can interact with CBD oil" title="Veterinary Drugs That Can Interact With CBD Oil Infograph" loading="lazy" width="1024" height="1024" style="float: none;"></div>
<h3>CBD and Fluoxetine for Dogs: Interactions</h3>
<p>Both of these options used together may depress a dogs respiratory or cardiac systems, and this can be dangerous. Don't use CBD and Fluoxetine together would clear and vice and monitoring from your veterinarian.</p>
<h3>CBD and Trazodone for Dogs: Interactions</h3>
<p><a href="https://lolahemp.com/blogs/pet-cbd/cbd-and-trazodone-dogs" title="This article discusses the use of CBD and trazodone at the same time in dogs.">CBD and Trazodone</a> may be used together if your veterinarian gives you the go-ahead. Used without caution, this combination can lead to serotonin syndrome, liver issues, and more.</p>
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<h3>CBD and Carprofen for Dogs: Interactions</h3>
<p>When used together, CBD and Carprofen may increase the risk of gastrointestinal issues such as ulcers or bleeding. The combination could also potentially affect liver function. Always consult with your veterinarian before combining these two treatments to ensure your dog’s safety.</p>
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<h3>CBD and Deracoxib for Dogs: Interactions</h3>
<p>CBD and Deracoxib can both affect your dog’s liver. Using these together without proper monitoring may increase the risk of liver damage or digestive issues. If your veterinarian prescribes both, it’s essential to closely monitor your dog’s health.</p>
</section>
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<h3>CBD and Firocoxib for Dogs: Interactions</h3>
<p>CBD may enhance the side effects of Firocoxib, such as kidney and liver problems. Combining these two could lead to complications, especially in dogs with pre-existing conditions. Always seek veterinary advice before using them together.</p>
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<h3>CBD and Meloxicam for Dogs: Interactions</h3>
<p>Meloxicam and CBD both have anti-inflammatory effects, but when used together, they may increase the risk of kidney toxicity or gastrointestinal upset. If prescribed together, your vet will likely recommend close monitoring to prevent side effects.</p>
</section>
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<h3>CBD and Oxycodone for Dogs: Interactions</h3>
<p>Combining CBD and Oxycodone can increase the sedative effects, leading to excessive drowsiness or even respiratory depression. Always consult with your veterinarian before using these two substances together, as the combination could be dangerous for your dog.</p>
</section>
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<h3>CBD and Hydromorphone for Dogs: Interactions</h3>
<p>Hydromorphone and CBD both have sedative effects. Using them together may amplify drowsiness and could lead to respiratory depression, which can be life-threatening. This combination should only be used under strict veterinary supervision.</p>
</section>
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<h3>CBD and Butorphanol for Dogs: Interactions</h3>
<p>Butorphanol, an opioid used for pain relief, combined with CBD may enhance the sedative effects, leading to extreme drowsiness or a slowed heart rate. Always consult with your veterinarian to monitor your dog closely if these two medications are prescribed together.</p>
</section>
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<h3>CBD and Prednisone for Dogs: Interactions</h3>
<p>Both CBD and Prednisone affect the immune system and can interact in unpredictable ways. While there are no major known interactions, long-term use of both could result in liver stress. Be sure to work closely with your vet to ensure safe and effective use of both medications.</p>
</section>
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<h3>CBD and Triamcinolone for Dogs: Interactions</h3>
<p>Triamcinolone is a corticosteroid, and using it alongside CBD may exacerbate potential side effects such as immune suppression or gastrointestinal issues. Always consult your veterinarian before combining these two medications to ensure proper monitoring and safety.</p>
</section>
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<h3>CBD and Hydroxyzine for Dogs: Interactions</h3>
<p>Hydroxyzine and CBD both have sedative effects, so using them together can lead to excessive sedation, drowsiness, or even difficulty breathing. Always consult your veterinarian before combining these medications, as this can result in serious side effects.</p>
</section>
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<h3>CBD and Diphenhydramine for Dogs: Interactions</h3>
<p>Diphenhydramine and CBD both have calming effects. When used together, they may cause excessive drowsiness or sedation. Use caution when combining these, and always consult with your veterinarian to ensure safety.</p>
</section>
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<h3>CBD and Chlorpheniramine for Dogs: Interactions</h3>
<p>Chlorpheniramine and CBD both have antihistamine properties, but using them together may increase the risk of drowsiness, sedation, and even respiratory depression. Always consult your vet before giving these medications together to ensure proper monitoring.</p>
</section>
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<h3>CBD and Diazepam for Dogs: Interactions</h3>
<p>Diazepam, a medication used for anxiety and muscle spasms, combined with CBD may lead to enhanced sedative effects, increasing the risk of respiratory issues or excessive drowsiness. This combination should only be used under the guidance of a veterinarian.</p>
</section>
<section>
<h3>CBD and Alprazolam for Dogs: Interactions</h3>
<p>Alprazolam is a medication commonly used for anxiety, and combining it with CBD could enhance the sedative effects, potentially causing excessive drowsiness or slowing of the heart rate. Always consult your veterinarian to determine if this combination is safe for your dog.</p>
</section>
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<h3>CBD and Some Antibiotics for Dogs: Interactions</h3>
<p>Certain antibiotics, like ciprofloxacin, may interact with CBD and cause changes in the metabolism of either drug. Always consult with your vet before using CBD alongside any antibiotics to prevent any possible adverse effects or reduced effectiveness of treatment.</p>
<h3>CBD and Gabapentin for Dogs</h3>
<p data-start="49" data-end="387">Gabapentin is commonly prescribed to dogs for pain management, seizures, and anxiety. <a href="https://www.lolahemp.com/blogs/dog-health/cbd-and-gabapentin-for-dogs" title="This article discusses the combination of CBD and gabapentin in dogs more specifically.">When combined with CBD</a>, there may be interactions that affect how either compound is metabolized in your dog’s system. Both CBD and gabapentin have sedative properties, which means using them together could potentially amplify drowsiness or lethargy.</p>
<p data-start="389" data-end="649" data-is-last-node="" data-is-only-node="">Additionally, CBD may influence the liver enzymes responsible for breaking down gabapentin, potentially altering its effectiveness. Always consult with your veterinarian before using CBD alongside gabapentin to ensure safe and effective treatment for your pet.<meta charset="utf-8"></p>
<h2><b>Liver Enzymes in the Cytochrome P450 Family</b></h2>
<p><span style="font-weight: 400;">Many pharmaceutical drugs are metabolized in the liver using specific enzymes. One group of these enzymes is known as the Cytochrome P450 family, or CYP450 group. These enzymes metabolize certain drugs, removing those drugs from the bloodstream. Dosing for such drugs is based on the proper functioning of this metabolic pathway. </span></p>
<p><span style="font-weight: 400;">If the CYP450 metabolic pathway is disrupted or inhibited, then the levels of certain drugs in the bloodstream will not be properly metabolized.</span></p>
<p><span style="font-weight: 400;">In some cases, this means that higher levels of those drugs stay in the bloodstream rather than being pushed out as waste in the liver. The real danger here is that it can create situations where there is too much of the pharmaceutical drug in the bloodstream, causing overdose or other complications in some cases. </span></p>
<p><span style="font-weight: 400;">For example, let’s take a look at a common blood thinner, warfarin. It is given to people with cardiovascular disease. </span></p>
<p><span style="font-weight: 400;">However, it is dosed with the assumption that the CYP450 metabolic pathway will remove some of the active compounds from the bloodstream at a reliable pace. If that process is inhibited by CBD, then it can cause too much of the blood thinner to be active in the blood, causing serious problems such as internal hemorrhaging. </span><b></b></p>
<h2><b>Can Other Things Interfere with the CYP450 Pathway?</b></h2>
<p><span style="font-weight: 400;">Yes. In fact, several scientific </span><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321138/" title="This study looks into drug interactions in dogs."><span style="font-weight: 400;">studies</span></a><span style="font-weight: 400;"> have shown that many other </span><span style="font-weight: 400;">foods</span><span style="font-weight: 400;"> and </span><span style="font-weight: 400;">supplements</span><span style="font-weight: 400;"> used in people can inhibit the CYP450 metabolic mechanisms. </span></p>
<p><span style="font-weight: 400;">Fewer studies have been done on dogs, but the working assumption is that the mechanisms of this metabolic pathway are similar in dogs and people.</span></p>
<div style="text-align: center;"><img src="https://cdn.shopify.com/s/files/1/0030/7435/9366/files/cbd_and_drug_interactions-min_grande_0ce445d4-ae66-4ff7-8872-4ad342d50980_large.jpg?v=1590559072" alt="Infographic of food and supplements that can inhibit CYP450 enzymes" title="Food and Supplements That Can Inhibit CYP450 Enzymes Infograph" loading="lazy" width="1024" height="1024" style="float: none;"></div>
<h2>Conclusion</h2>
<p>As you can see, there are a handful of drugs that could interact with CBD in dogs. So, if your dog is using medications, it's vital that you discuss this with your veterinarian. </p>
<p>It's always a good idea to discuss CBD with your veterinarian before use, even if they're not actively on any medications. </p>
</section>

Which Drugs Can Interact with CBD?

About 60% of pharmaceutical drugs used in human medicine use the CYP450 metabolic pathway. In veterinary medicine, many of the drugs prescribed to our pets also use this metabolic pathway. Please consult with your vet about the use of CBD oil if your dog is taking any other medications.

Represented in the table below are some of the more commonly prescribed veterinary drugs that can interact with CBD. Note: this is not an exhaustive list, so again, it is critical to consult with your vet first.

Infographic of veterinary drugs that can interact with CBD oil

CBD and Fluoxetine for Dogs: Interactions

Both of these options used together may depress a dogs respiratory or cardiac systems, and this can be dangerous. Don't use CBD and Fluoxetine together would clear and vice and monitoring from your veterinarian.

CBD and Trazodone for Dogs: Interactions

CBD and Trazodone may be used together if your veterinarian gives you the go-ahead. Used without caution, this combination can lead to serotonin syndrome, liver issues, and more.

CBD and Carprofen for Dogs: Interactions

When used together, CBD and Carprofen may increase the risk of gastrointestinal issues such as ulcers or bleeding. The combination could also potentially affect liver function. Always consult with your veterinarian before combining these two treatments to ensure your dog’s safety.

CBD and Deracoxib for Dogs: Interactions

CBD and Deracoxib can both affect your dog’s liver. Using these together without proper monitoring may increase the risk of liver damage or digestive issues. If your veterinarian prescribes both, it’s essential to closely monitor your dog’s health.

CBD and Firocoxib for Dogs: Interactions

CBD may enhance the side effects of Firocoxib, such as kidney and liver problems. Combining these two could lead to complications, especially in dogs with pre-existing conditions. Always seek veterinary advice before using them together.

CBD and Meloxicam for Dogs: Interactions

Meloxicam and CBD both have anti-inflammatory effects, but when used together, they may increase the risk of kidney toxicity or gastrointestinal upset. If prescribed together, your vet will likely recommend close monitoring to prevent side effects.

CBD and Oxycodone for Dogs: Interactions

Combining CBD and Oxycodone can increase the sedative effects, leading to excessive drowsiness or even respiratory depression. Always consult with your veterinarian before using these two substances together, as the combination could be dangerous for your dog.

CBD and Hydromorphone for Dogs: Interactions

Hydromorphone and CBD both have sedative effects. Using them together may amplify drowsiness and could lead to respiratory depression, which can be life-threatening. This combination should only be used under strict veterinary supervision.

CBD and Butorphanol for Dogs: Interactions

Butorphanol, an opioid used for pain relief, combined with CBD may enhance the sedative effects, leading to extreme drowsiness or a slowed heart rate. Always consult with your veterinarian to monitor your dog closely if these two medications are prescribed together.

CBD and Prednisone for Dogs: Interactions

Both CBD and Prednisone affect the immune system and can interact in unpredictable ways. While there are no major known interactions, long-term use of both could result in liver stress. Be sure to work closely with your vet to ensure safe and effective use of both medications.

CBD and Triamcinolone for Dogs: Interactions

Triamcinolone is a corticosteroid, and using it alongside CBD may exacerbate potential side effects such as immune suppression or gastrointestinal issues. Always consult your veterinarian before combining these two medications to ensure proper monitoring and safety.

CBD and Hydroxyzine for Dogs: Interactions

Hydroxyzine and CBD both have sedative effects, so using them together can lead to excessive sedation, drowsiness, or even difficulty breathing. Always consult your veterinarian before combining these medications, as this can result in serious side effects.

CBD and Diphenhydramine for Dogs: Interactions

Diphenhydramine and CBD both have calming effects. When used together, they may cause excessive drowsiness or sedation. Use caution when combining these, and always consult with your veterinarian to ensure safety.

CBD and Chlorpheniramine for Dogs: Interactions

Chlorpheniramine and CBD both have antihistamine properties, but using them together may increase the risk of drowsiness, sedation, and even respiratory depression. Always consult your vet before giving these medications together to ensure proper monitoring.

CBD and Diazepam for Dogs: Interactions

Diazepam, a medication used for anxiety and muscle spasms, combined with CBD may lead to enhanced sedative effects, increasing the risk of respiratory issues or excessive drowsiness. This combination should only be used under the guidance of a veterinarian.

CBD and Alprazolam for Dogs: Interactions

Alprazolam is a medication commonly used for anxiety, and combining it with CBD could enhance the sedative effects, potentially causing excessive drowsiness or slowing of the heart rate. Always consult your veterinarian to determine if this combination is safe for your dog.

CBD and Some Antibiotics for Dogs: Interactions

Certain antibiotics, like ciprofloxacin, may interact with CBD and cause changes in the metabolism of either drug. Always consult with your vet before using CBD alongside any antibiotics to prevent any possible adverse effects or reduced effectiveness of treatment.

CBD and Gabapentin for Dogs

Gabapentin is commonly prescribed to dogs for pain management, seizures, and anxiety. When combined with CBD, there may be interactions that affect how either compound is metabolized in your dog’s system. Both CBD and gabapentin have sedative properties, which means using them together could potentially amplify drowsiness or lethargy.

Additionally, CBD may influence the liver enzymes responsible for breaking down gabapentin, potentially altering its effectiveness. Always consult with your veterinarian before using CBD alongside gabapentin to ensure safe and effective treatment for your pet.

Liver Enzymes in the Cytochrome P450 Family

Many pharmaceutical drugs are metabolized in the liver using specific enzymes. One group of these enzymes is known as the Cytochrome P450 family, or CYP450 group. These enzymes metabolize certain drugs, removing those drugs from the bloodstream. Dosing for such drugs is based on the proper functioning of this metabolic pathway.

If the CYP450 metabolic pathway is disrupted or inhibited, then the levels of certain drugs in the bloodstream will not be properly metabolized.

In some cases, this means that higher levels of those drugs stay in the bloodstream rather than being pushed out as waste in the liver. The real danger here is that it can create situations where there is too much of the pharmaceutical drug in the bloodstream, causing overdose or other complications in some cases.

For example, let’s take a look at a common blood thinner, warfarin. It is given to people with cardiovascular disease.

However, it is dosed with the assumption that the CYP450 metabolic pathway will remove some of the active compounds from the bloodstream at a reliable pace. If that process is inhibited by CBD, then it can cause too much of the blood thinner to be active in the blood, causing serious problems such as internal hemorrhaging.

Can Other Things Interfere with the CYP450 Pathway?

Yes. In fact, several scientific studies have shown that many other foods and supplements used in people can inhibit the CYP450 metabolic mechanisms.

Fewer studies have been done on dogs, but the working assumption is that the mechanisms of this metabolic pathway are similar in dogs and people.

Infographic of food and supplements that can inhibit CYP450 enzymes

Conclusion

As you can see, there are a handful of drugs that could interact with CBD in dogs. So, if your dog is using medications, it's vital that you discuss this with your veterinarian.

It's always a good idea to discuss CBD with your veterinarian before use, even if they're not actively on any medications.

References: